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The conjugation of tumor-targeting carriers could substantially improve the treatment specificity, yet the macromolecular nature of the carriers often complicates the pharmacokinetic profiles of the prodrugs in the circulation, affecting their biodistribution, metabolism and clearance

however, upon lethal levels of ROS and/or severe DNA damage, cells cannot be repaired and saved, then they would be eliminated permanently by high levels of p53-mediated cell death

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Glutathione is vital to cartilage health since cartilage is particularly susceptible to age-related glutathione oxidation