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Abnormally elevated levels of DRP1 not only cause mitochondrial fission, mitochondrial fragmentation, and decreased efficiency of mitochondrial ATP production but also impede glucose uptake (104) and glucose-stimulated insulin secretion by inhibiting the translocation of the insulin receptor substrate 1-protein kinase B (IRS1-Akt) pathway and glucose transport proteins in mouse pancreatic -cells (105)

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Despite these encouraging findings, the evidence is fraught with inconsistencies and methodological limitations

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[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Schmidt-Sommerfeld E, Penn D, Kerner J, Bieber LL, Rossi TM, Lebenthal E