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For each incremental standard deviation in Ruminococcus2 abundance, there was a corresponding 26% reduction in NAFLD risk (OR=0.74, 95%CI=0.610.89, P=0.0012), accompanied by a 17% increase in cysteine-glutathione disulfide levels (OR=1.17, 95%CI=1.011.37, P=0.041) and an 18% increase in 3-indoleglyoxylic acid levels (OR=1.18, 95%CI=0.81-1.00, P=0.036)

Cytochrome P450 family 51 subfamily A member 1 (CYP51A1), a conserved sterol 14-demethylase essential for cholesterol synthesis, exemplifies this emerging concept

M., Williams C

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