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PubMed 5.Staresinic M et al

J.PourfarzadF.AartsC

Over-application, prolonged contact, or use on compromised skin can precipitate systemic toxicity, manifesting as circumoral numbness, dizziness, tinnitus, seizures, arrhythmias, or profound CNS depression

This difference is explained further in the comparison of IV therapy vs oral supplements

The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein

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