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Additionally, Gossypol Acetic Acid was reported to alleviate ferroptosis in OA chondrocytes by inhibiting GPX4 methylation (Shang et al., 2025)

The activities of glutathione peroxidase (GPH-Px), total superoxide dismutase (T-SOD), catalase (CAT), total antioxidant capacity (T-AOC) and contents of malondialdehyde (MDA) and hydrogen peroxide (H 2 O 2 ) were quantified using the respective assay kits Nanjing Institute of Jiancheng Biological Engineering, Nanjing, China, according to the manufacturers protocols

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