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Trazodone follows biphasic elimination, clearing in two phases: a fast early drop within about 1 hour, then a slower removal phase lasting 10 to 12 hours

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Menopause already causes insulin resistance in roughly 60% of women, creating a vicious cycle of weight gain, metabolic dysfunction, and thermoregulatory chaos

Incorrect dosages can invalidate findings or, in research-clinical contexts, produce unsafe outcomes

In a review of 18 studies, eleven trials reported a positive effect of B vitamins on improving overall mood or a facet of mood, with the most significant benefits to stress