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Luspatercept Sotatercept S2.1.5 INNATE REPAIR RECEPTOR AGONISTS, E.G

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It exhibits high reactivity toward nucleophiles in vivo, making it toxic [27,28,29]

Because it contains no fat, it does not trigger the gallbladder to contract forcefully, nor does it require a large amount of bile to be processed

Unfortunately, this compensatory surge is futile because the downstream clearance pathwaysspecifically the enzymes mitochondrial superoxide dismutase (SOD2) and glutathione peroxidase 4 (GPX4)are severely dysfunctional

Why We Picked Them: Luis Martinez, MD leads the clinical team