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There is evidence of the use of tea for health purposes dating back about 3,000 years

ABCB6 and its functional homolog Heavy Metal Tolerance factor 1 (HMT-1) are essential for detoxifying heavy metals in various species including human , Rattus norvegicus , Caenorhabditis elegans , Drosophila melanogaster , Schizosaccharomyces pombe , and Chlamydomonas reinhardtii 23,33,34,35

As described above, the Lys8 residue is also involved in the direct binding to AsA and the W1-mediated hydrogen bond with GSH

Borthakur G, Nagler A, Ofran Y, Rowe J, Altman JK, Frankfurt O, Tallman MS, Avivi I, Peled A, Pereg Y, Foley-Comer A, Russovsky L, Aharon A, McQueen T, Pemmaraju N, Bueso-Ramos C, Cortes J, Andreeff M

Chan et al., One-carbon metabolism provides units to support growth and proliferation when nutrient availability and energy levels are high

While the mechanistic details of this function remain to be fully elucidated, accumulating evidence points to important roles for glutathione and glutathione-dependent proteins in phytohormone signaling and in defense against biotic stress