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Bile duct ligation (BDL) caused obstructive jaundice, abnormal liver function, increased lipid peroxide levels, and decreased GSH levels in rats, which indicated that oxidative stress in rats with obstructive jaundice was observed

6b), indicated a significant downregulation of genes within the transforming growth factor (TGF) signalling pathway, a main regulator of hepatic fibrosis 51 ( Tgfb1 , Tgfb2 , Tgfbr1 and Tgfbr2 ) as well as key genes related to ECM remodelling ( collagen , type I , -1 ( Col1a1 ), Col1a2 and Col4a1 ) in mice overexpressing AGXT

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Acknowledgments DP-F thanks Fundao Carlos Chagas Filho de Amparo Pesquisa do Estado do Rio de Janeiro (FAPERJ), TN, and AN thanks CAPES, and KC and PC-C thank Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq) for individual research fellowship