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Some experiments have been performed with 10mM but several experiments have tested dose-responses effects from 1 to 10 mM

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Jha JC, Banal C, Okabe J, Gray SP, Hettige T, Chow BSM, et al

280 Shank3 protein is a negative regulator of Parkin-mediated mitophagy and is enriched in the heart with increasing aging

The combination of these R 8 GD modified liposomes demonstrated potent toxicity against highly invasive breast cancer (MDA-MB-435S) cells, effectively suppressing the formation of vasculogenic mimicry (VM) channels, and inhibiting tumor cell metastasis by down-regulating HIF-1 , MMP-2, TGF- 1 and VE-cad [442]