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A multi-Centre study in China examining 78,952 semen samples from 33,234 donors indicated that both thermal extremes negatively impacted sperm parameters, with heat-related anomalies during the warm season significantly diminishing sperm concentration and motility (130)

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In human lung cancer cells, NRF2 regulates serine biosynthesis via activating transcription factor 4 (ATF4) and phosphoglycerate dehydrogenase (PHGDH) to support GSH and nucleotide production and coordinately activates the pentose phosphate pathway (PPP) to supply ribose for nucleic acid biosynthesis (29, 107)

To this end, we engineered S