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Regrettably, hepatotoxicity triggered by DB treatment vastly restricts its application in clinic although evidence has demonstrated that low-dose DB combined with targeting gene therapy specifically kills cancer cells not normal hepatocytes [38, 39]

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In fact, the ratio of reduced glutathione to oxidized glutathione within cells is often used scientifically as a measure of cellular toxicity

The anticancer properties of silibinin: its molecular mechanism and therapeutic effect in breast cancer

Figure 4figure supplement 2C & D

doi: 10.3390/ijms21041505 59 KayaH.NakajimaR.IwanoM.KanaokaM