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Antimicrobial resistance in Listeria species

Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKC enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells

Oxidative stress then accelerates the aggregation of -synuclein which subsequently binds and sequesters available GSH, creating a destructive feedback loop of protein misfolding and antioxidant loss (Hoepken et al., 2007)

This therapeutic strategy might be beneficial for the generation of CAR T cells when targeting tumors in highly oxygenated tissues