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Matsushita M, Shichiri M, Imai T, Iwashina M, Tanaka H, Takasu N, Hirata Y

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In individuals with primary coenzyme Q 10 deficiency, early treatment with high-dose coenzyme Q 10 supplementation (1030 mg/kg/day in children and 1.23.0 g/day in adults) may improve the pathological phenotype, yet the effectiveness depends on the type of mutations affecting the coenzyme Q 10 biosynthetic pathway (1, 26)

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A biotin deficiency can lead to brittle hair and nails

Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice