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This review comprehensively elucidates the regulatory networks of ferroptosis in OS, with a specific focus on the System Xc/Glutathione Peroxidase 4 (GPX4) antioxidant axis and lipid metabolism

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This article begins with an overview of basic pathological mechanisms and offers a comprehensive overview of relevant therapeutic approaches and future development directions, aiming to facilitate the transition of the field from traditional generalized therapies to personalized precision medicine and to bridge the long-standing gap between basic research and clinical practice.