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Description
APR-246 exhibits anti-leukemic activity and synergism with conventional chemotherapeutic drugs in acute myeloid leukemia cells

Milinkeviciute G, Tran K, Da Cunha C, Mendoza-Arvilla A, Garcia-Agudo LF, Neumann J, Walker A, Kawauchi S, Tenner AJ, LaFerla F, et al

The possible role of MMR defects in drug resistance in ovarian cancer deserves further investigation

Accordingly, the unique genomic map of SARS-CoV-2 virus and the extent of its mediated virushost proteinprotein interactions that trigger human metabolic reprogramming and dysregulation (HMRD) in favor of the virus life cycle, defines the ultimate severity and fate of COVID-19 23,24,25,26

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Because these reactions are reported voluntarily from a population of uncertain size and may include abuse of other agents, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure
