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Overall, structural modifications, including the stapling motif ( i,i + 7), specific positioning of the staple, N- and C-terminal residues, conservation of leucine side chains, and preservation of charged/polar residues D146, E151, and N153 directed the improved potency and specificity of 1907 as a FAK scaffold inhibitor

doi: 10.3390/biology12050676 64 TaghilooSAjamiAAlizadeh-NavaeiRAsgarian-OmranH

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Presented at the American Chemical Society Meeting, Washington, D.C., August 20, 2000 (www.acs.org/portal/Chemistry- PID=acsdisplay.html&DOC=daily\ sunday\weight.html)

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F., Tierney, M