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In summary, rational design has led to the development of two long-acting GLP-1 analogs, liraglutide and semaglutide, that have made a vast contribution to the management of T2D in terms of improvements in glycemic control, body weight, blood pressure, lipids, beta-cell function, and CV outcomes

[DOI] [PMC free article] [PubMed] [Google Scholar] Sun W-M, Huang Z-Z, et al

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