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Additionally, metabolite analysis of FDX1-knockout human chronic myelogenous leukemia K562 cells reveals the accumulation of pyruvate and alpha-ketoglutarate in the lipoic acid metabolic pathway, suggesting inhibition of the tricarboxylic acid cycle

10.1038/s41588-018-0135-7 Summary Keywords gut microbiota, irritable bowel syndrome of constipation, metabolomics, metagenomics, dysbiosis Citation Wang Y-L, Xu X-Q, Long Y-Y and Cheng Y-L (2025) Characterization of gut microbiota and metabolites in individuals with constipation-predominant irritable bowel syndrome

Immunological testing G01N33/68Chemical analysis of biological material, e.g

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This appears to be dose-dependent, with moderate doses enhancing sleep quality while excessive doses may paradoxically impair deep sleep architecture

Filtered reads were then paired-end merged again, and chimeras and non-bacterial sequences were discarded from the data