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When accumulated nanoparticles detect high levels of ROS in the TME, the therapeutic drug is released, which is more precise and efficient [68]

In the effort to modify their lifestyle, the couple, in fact, may have a dramatic impact

Table 1C, in section VI

The substitution of curcumins -diketone linker with a cyclohexanone structure eliminates the central methylene group, impairing hydride transfer and -alkoxyl radical generation, both of which are important for phenoxy radical formation and antioxidant activity

this is a likely mechanism by which drug dependency is fomented and perpetuated
Med 2000, 172, 186189
