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Thus, non-NMDA-Rs activation is necessary to depolarize the neurons allowing NMDA-Rs activation

In murine models, higher doses resulted in increased nAb production, whereas lower doses may fail to achieve sufficient transduction of target cells and, therefore, may not provide the desired therapeutic effect

As with all applications, this requires careful medical oversight due to the compounds potency and the limited long-term human safety data available

This makes it a pleiotropic regulator , a molecule that modulates many processes, all of which are important for regeneration and slowing of ageing

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