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Ribonucleotide reductase plays a pivotal role in DNA synthesis and repair and is a target of currently used cancer therapeutic agents, such as hydroxyurea (23)

Furthermore, while Vitamin B6 is essential, excessive long-term intake of standard pyridoxine can cause neuropathy

E.VinayagamR.SinghM.KangS

Signs include severe rash, itching, hives, or trouble breathing

Furthermore, it has been proposed that the DNA damage and cell apoptosis caused by bilirubin and phototherapy in newborns with hyperbilirubinemia may be associated with the downregulation of the BCL-2 gene (which can inhibit apoptosis) and the upregulation of the BAX gene (which can promote apoptosis) (10)

Sui H, Wang F, Weng Z, et al