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Mice engineered to overexpress a single-chain variable fragment of E06, an IgM NAb directed against oxidized phospholipids (oxPL), were found to have reduced atherosclerosis and features consistent with greater overall plaque stability, confirming the atheroprotective nature of these B-1 cell-derived antibodies (94)

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Beyond their reactivity in stroke, astrocytes also exhibit a form of autophagy plasticity, dynamically adjusting autophagic activity in response to pathological stimuli such as A accumulation

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Binder DK, Scharfman HE (2004) Brain-derived neurotrophic factor

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