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Interestingly, the transition from cognitively normal PD, through mild cognitive impairment, to PD dementia (PDD) is marked by a decrease in parietal-occipital metabolism, which may be an early predictor of dementia in PD [42]

126,127 In contrast, memantine, another non-selective NMDA antagonist, failed to show greater efficacy than placebo in a 90-day prospective randomized double-blind crossover trial

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A schistosome-expressed immunomodulatory glycoconjugate expands peritoneal Gr1 + macrophages that suppress naive CD4 + T cell proliferation via an IFN- and nitric oxide-dependent mechanism