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Despite unquestionable essentiality of copper, unregulated copper ions may increase oxidative damage

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The reason most peptide guides get this wrong is that they apply pharmacokinetic models designed for small-molecule drugs (where receptor binding and plasma concentration are tightly coupled) to peptides with entirely different mechanisms

The lentivirus for ER, OXTR, or empty control (CTL) was expressed through Lenti-X TM Lentiviral Expression Systems (from Clontech) per manufacturers instructions ( Gene Knockdown by shRNA Lentivirus Particles The shRNA lentivirus particles for human ER and SOD2 were prepared as described previously in our lab ( TM Lentiviral Expression Systems (from Clontech) per manufacturers instructions