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After binding with PERK, TMAO selectively activates PERK-mediated UPR, thereby promoting metabolic dysfunction ( Of note, TMAO in the pathogenesis of Alzheimers disease (AD) indicated that PERK is not the only mechanism by which TMAO induces UPR

[DOI] [PubMed] [Google Scholar] 271

Ikonomidou C, Kaindl AM

10.3389/fchem.2018.00243 Front

Inhibition of human cytochrome P450 enzymes by constituents of St Johns Wort, an herbal preparation used in the treatment of depression

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