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Microglial activation reduction: Retinal microglia (resident immune cells) become activated in disease states releasing inflammatory mediators and reactive oxygen species

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On top of 2D cultures, 3D cerebral organoids are also increasingly being explored as avenues of research into AD pathology, successfully modelling cell interactions, depicting A plaque buildup and phosphorylated tau accumulation [44]

Front Immunol (2020) 11:561724

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Compared with conventional single-target strategies, the combined system provides synergistic regulation across multiple signaling pathways