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doi: 10.1016/j.jhazmat.2020.124923 85

identified the lncRNA LINC01127 as a factor that exerts detrimental effects which is linked to lactylation modifications and LPS produced by the gut microbiota in colorectal cancer patients [150]

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It is important to acknowledge that this thio-disulfide exchange based protein oligomerization inducer may face several challenges: (i) so far, it has only been tested on WDR5, and further exploration is needed to determine its applicability to other proteins, (ii) the disulfide bonds induced by WZ-1 are susceptible to cleavage under strong reducing conditions, so we need to develop strategies to ensure stable linkages that remain unaffected by intracellular environments, (iii) challenges persist in translating oligomerization inducers into viable drugs, primarily stemming from unforeseen oligomerization scenarios, such as excessive oligomerization and off-target proteins interactions

a continuous metabolic effect of standard ketogenic or medium chain triglyceride (MCT) oil-supplemented diet