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Although the limited ability of paclitaxel to cross the intact bloodbrain barrier initially suggested indirect mechanisms of action, research now indicates that paclitaxel can indeed reach brain tissue, particularly the hippocampus, at concentrations sufficient to induce neurotoxicity (Tang et al., 2022)

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Accordingly, drug-mediated regulation of Wnt/-catenin signalling activity to induce liver regeneration would benefit this group of patients based on the key role of Wnt/-catenin signalling in the pathobiology of non-tumour diseases such as steatohepatitis, 78,310 cholestasis, 311 and liver fibrosis

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Methyl isocyanate, mentioned earlier, is an example of a compound that is distributed throughout the body by reversible, glutathione S -conjugate formation