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This p21/Nrf2 axis has been demonstrated to be a critical inhibitor of ferroptosis, and notably, this activation can occur through both p53-dependent and p53-independent mechanisms 40

Conflicts of Interest Rosario Russo was employed by the company Giellepi S.p.A

Many of the studies reviewed highlight promising behavioral, neurochemical, or microbiota-related effects of probiotic and prebiotic interventions, yet very few include direct measurements of oxidative-stress biomarkers

[DOI] [PubMed] [Google Scholar] 161.Xu H., Becker C.M., Lui W.T., Chu C.Y., Davis T.N., Kung A.L., Birsner A.E., DAmato R.J., Wai Man G.C., Wang C.C

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It does not alter neuromuscular junction electrophysiology