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The preformed aggregates were re-suspended in PBS at a final protein concentration of 0.2 mg ml 1 and were treated with 500 M sterols in 500 M DPPC liposome and incubated at 37 C for 24 h

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Second-generation protease inhibitors: simeprevir, faldaprevir, and vaniprevir Simeprevir (TMC435) is an oral, once-daily (QD), HCV NS3/4A macrocyclic protease inhibitor with potent antiviral activity in HCV genotype 1-infected patients as well as HCV genotypes 2, 4, 5 and 6

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