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Furthermore, in animal models, glycyrrhizin has been shown to inhibit the activation of hepatic stellate cells (HSCs) and induce their apoptosis by blocking NF-B nuclear translocation, thereby preventing liver fibrosis ( 3.1.2 Interference with arachidonic acid cascade In an lipopolysaccharide (LPS)-stimulated macrophage model, researchers found that MgIG inhibited the activation of PLA 2 in LPS-stimulated macrophages ( 2 (PLA 2 ) is the key initiating enzyme of the arachidonic acid cascade, responsible for catalyzing the hydrolysis of membrane phospholipids to release arachidonic acid

Amplify the inflammatory effect

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doi: 10.1093/nar/15.17.7178

Abdul-Nashirudeen, M

Data are presented as means 95% confidence intervals (CIs) unless otherwise stated