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By analogy with semaglutide (where the STEP-4 withdrawal trial demonstrated substantial weight regain within 12 months of discontinuation), researchers should anticipate that weight regain is likely following cessation of any GLP-1 class compound, including retatrutide

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Auto-Abs may block the E3 ligase-dependent ubiquitination process through which TRIM21 elicits its functions, which may result in overexpression of interferons [201]

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