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The activation of astrocytes and the release of modulators from these stimulated cells have been implicated in neuropathic pain of various origins [110], including paclitaxel-induced CIPN [107, 109]

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The major pathways for the central nervous system (CNS) toxicity could be related to increased neuronal and glial injury due to metabolic impairment linked to mitochondrial dysfunction

Vitamin D also inhibits the destruction mechanisms of nerve cells

However, about 2570% of virus-free COVID-19 survivors continue to sustain virus-induced HMRD and exhibit a wide range of symptoms that are persistent, exacerbated, or new onset clinical incidents, collectively termed as post-acute sequelae of COVID-19 (PASC) or long COVID

Polyphenols as promising bioactive compounds