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Finally, we must not forget that AD is not a dysmetabolism that can be solved by administering the missing metabolite

Despite decades of clinical research, randomized controlled trials (RCTs) targeting previously identified molecules such as IL-1 and IL-6 have failed to produce the expected results

Also, mean ALP and LDH activity were lower in the intervention compared to the control group significantly ( p = 0.010 and p = 0.002, respectively

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3,6 From Table 1, the number needed to treat (NNT) for the first-line agents range from 1.3 for lacosamide to 8.7 for mirogabalin

doi: 10.1097/01.psy.0000116249.60477.e9