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Asymptomatic smokers and stable COPD patients showed increased GSH levels in bronchoalveolar lavage, while patients with severe/very severe exacerbation periods had significantly decreased levels (101)

It catalyzes the conversion of free long-chain fatty acids into acyl-CoA derivatives, facilitating their integration into cell membranes ( 2.1.4 Iron-responsive element-binding protein 2 Other molecules involved in lipid and iron metabolism also regulate ferroptosis, including iron-responsive element-binding protein 2 (IRP2) ( 2.2 Organelle-specific regulation of ferroptosis Organelle interactions are fundamental to the regulation of ferroptosis and include various cellular compartments such as mitochondria and the endoplasmic reticulum (ER), which work in conjunction with lipid metabolic pathways ( Figure 2 )

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