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If pralidoxime is administered before adequate atropinization , it may temporarily worsen life-threatening muscarinic effects, including: Bronchoconstriction Increased respiratory secretions , which can lead to airway obstruction Therefore, clinical guidelines recommend administering atropine before pralidoxime , and this sequence is reflected in autoinjector design (Aman et al., 2021
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Diabetes Care 47 (2024)
Free Radic Biol Med 129:5972
doi: 10.1111/bjh.12959 214
In a phase I/II open-label single-center study, A1AT was administered as salvage therapy to 12 patients with SR-aGVHD
