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Once the underlying biotypes improve, parents frequently report: calmer mood fewer meltdowns increased eye contact reduced sensory defensiveness better sleep improved speech more flexible thinking stronger social engagement These are outcomes that drug-based approaches, by themselves, rarely accomplish

JAMA Netw Open 5(5):e2213588, 2022

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While a variety of withdrawal symptoms have been described in association with clomipramine hydrochloride discontinuation (see PRECAUTIONS, Withdrawal Symptoms), there is no evidence for drug-seeking behavior, except for a single report of potential clomipramine hydrochloride abuse by a patient with a history of dependence on codeine, benzodiazepines, and multiple psychoactive drugs