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Male wild-type (WT) mice and Gpx1 KO mice were intravenously injected with Con A (10mg/kg), and then killed after 8h after Con A injection

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Furthermore, the hippocampal metabolomic analysis indicated that sleep deprivation affected the metabolism of fatty acid and oxylipins, upregulated the tryptophan-kynurenine metabolic pathway, and exhibited a significant correlation with anxiety and depressive behaviors

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