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Mini-gut organoids: reconstitution of the stem cell niche
This activation leads to the upregulation of various cytoprotective and antioxidant proteins
In this cascade, the activation of caspase-1 within the inflammasome complex leads to the cleavage of gasdermin-D (GSDMD) and the precursors of interleukin-1 (IL-1) and interleukin-18 (IL-18), marking the cell for pyroptotic death (Martinon et al., 2002
In the past few years, it has been observed a correlation between the ECS and the synthesis of ROS/RNS
It consists of three phases: anagen (growth), catagen (transition), and telogen
