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Eritadenine can significantly lower the triglyceride levels in plasma, but it is also involved in increasing triglyceride concentration in the liver

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In chronic HIV infection, persistent mtDNA leakage sustains this pathway, contributing to the elevated IFN-inflammatory signature characteristic of individuals even on ART

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These findings suggest that targeted inhibition of ferroptosis pathways may represent a viable option for treatment of therapy-resistant metastatic disease