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Innate immunosensing of DNA in cellular senescence
The mechanism by which IGF-1R signaling mediates radioresistance is thought to be associated with diminished -H2AX foci, which normally promote the resolution of irradiation-induced DNA double-strand breaks (DSBs) via both homologous recombination (HR) and the classical nonhomologous end joining (C-NHEJ) pathway (Figure 2) [41]

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doi: 10.1016/j.lfs.2024.122439 219 LiuLYeYLinRLiuTWangSFengZet al

Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome

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