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This shift increases pro-inflammatory cytokines, such as IL-12, and decreases immunosuppressive cytokines like IL-10, enhancing the immune response within the tumor microenvironment

These data support a central role for reversal of exhaustion in the leukemic microenvironment as necessary for effective GVL after DLI

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5.2 Spinal visceral pathways Due to a rostrocaudal shift in innervation ratio, the predominant afferent innervation of the proximal GI tract is provided through the vagus nerve, while the distal GI tract is mostly innervated by afferent spinal projections (Harrington et al., 2018)

At this time, just add the amount of water you need and bring it to a boil
