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Cuprizone-brain damage and motoric disability The used cuprizone regimen, several times higher than those regularly used in cuprizone studies (62), rapidly induced marked functional disability along with severely affected various brain areas

Consistent with this notion, studies in mouse models have shown that knockdown of GLO-1 using shRNA constructs leads to enhanced tumor growth, further supporting a complex and context-dependent role for GLO-1 in tumorigenesis and cancer progression (37)

The validation criteria were established in accordance with widely accepted guidelines for bioanalytical method validation, such as the FDA Guidance for Industry [71]

(2023) used CRISPR/Cas9 to knock out OsGSTU17 , leading to decreased GSH contents and hypersensitivity to cadmium, showing its role in GSH-dependent metal detoxification

Nat Biotechnol, 2019, 37: 13221331 Wu Y, Huang S, Wang J, et al

10.3945/jn.109.113332 53 HodgesR
