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The mRNA and protein expression of the GSH biosynthesis pathway (GCLC, GCLM, GSS, and GSR) were downregulated in GCLC knockdown cells (Fig

Morphological abnormalities of the mitochondria have been reported in ALD cell models, mice, and patients [109,110,111], highlighting the contribution of the mitochondria as an underlying pathological mechanism of peroxisomal disorders

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Aside from generating both NADPH and ribose 5-phosphate, the PPP can operate four different modes where NADPH and/or ribose 5-phosphate is produced, depending on the cellular metabolic demands (Fig

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Nucleic Acids Res 42:D503509 Reis ES, Mastellos DC, Hajishengallis G, Lambris JD (2019) New insights into the immune functions of complement