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Vitamin B-12 deficiency symptoms may include: strange sensations, numbness, or tingling in the hands, legs, or feet difficulty walking (staggering, balance problems) anaemia a swollen, inflamed tongue difficulty thinking and reasoning (cognitive difficulties), or memory loss weakness fatigue While an experienced physician may notice the symptoms and be able to detect a vitamin B-12 deficiency with a good interview and physical exam, a blood test is needed to confirm the condition

All other datasets generated and analysed during the present study are available in the Supplementary Tables

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Metabolic pathway enrichment analysis revealed that CAR T cell products of LTR have significantly increased pools of TCA metabolites, nucleotide biosynthesis intermediates, sphingolipid metabolism, and intermediates in central energy metabolism, as well as significantly decreased nucleotide catabolic and tRNA metabolism intermediates, which is critical for T cell activation 10 , compared to those of STR (Fig

An antioxidant stops oxidation and its free radicals by neutralizing them with an infusion of electrons