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This reduction in FGF18 protein stabilization decreases its interaction with SNF2 related chromatin remodeling ATPase 5 (SMARCA5), thereby repressing the chromatin accessibility of the SMAD family member 4 ( SMAD4 ) promoter and activating the SMAD4-dependent pathway [102]

Muscle and bone loss can also occur, leading to conditions such as osteoporosis (Mozaffarian et al

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Cardiovascular Health BenefitsMay help lower triglycerides, total cholesterol, and LDL, supporting heart health and reducing atherosclerosis risk

[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Coort S., Niessen H., Koonen D., Coumans W., Bonen A., Vandervusse G., Glatz J., Luiken J
