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Biomed Res Int 2018:115 Rowe RC, Sheskey PJ, Quinn ME (2009) Handbook of pharmaceutical excipients, sixth edition

Structurally, GME is a homodimeric enzyme that belongs to the short-chain dehydrogenase/reductase protein superfamily (Wolucka et al., 2001), which shares the extended Rossmann fold with a modified glycine-rich nucleotide-binding domain (GAGGFIA instead of GXGXXG) involved in NAD(P)-binding, a catalytic triad ([ST]xnYx3K) and similar mechanisms of catalysis (Persson and Kallberg, 2013
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