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This type of BIM protein promotes drug resistance in NSCLC (non-small cell lung cancer) and CML (chronic myeloid leukemia) against tyrosine kinase inhibitors such as gefitinib and imatinib [67]

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Notably, oral primary bile acid supplementation is effective and can avoid patient deterioration and the need for liver transplantation upon timely treatment [81, 82]

10.1016/j.biopha.2019.109415 215 LiaoM.QinR.HuangW.ZhuH

However, before these biomarkers can be adopted into routine clinical use, further standardization, cost-effectiveness evaluation, and regulatory validation are required

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