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3.5 Dysregulated collagen metabolism In parallel to various signaling cascades, dysregulation in collagen metabolism and homeostasis also contributes to OSFs pathogenesis (Cabral-Pacheco et al., 2020), and LOX activity, which is responsible for the intra- and inter-molecular cross-linking of non-degradable (proteolytic degradation) collagen fibrils ( OSF histological progression can be categorized into four stages based on collagen formation and accumulation, which include (i) very early, (ii) early, (iii) moderately advanced, and (iv) advanced

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PMID 16093404

Regulation of the effector function of CD8(+) T cells by gut microbiota-derived metabolite butyrate

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